Biological Systems: Theory and Innovation

Prospects for the use of growth stimulators based on nitrogen-containing heterocycles in plant propagation technologies

Mykhailo Zavhorodnii, Viktoriia Gencheva, Vasyl Shupeniuk, Oleksandr Brazhko, Valerii Horban
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Abstract

Nitrogen-containing heterocycles have attracted the attention of researchers as compounds widely represented in the structures of both natural and synthetic plant growth regulators. The relevance of using natural and synthetic growth regulators in plant propagation is extremely high, as they play a key role in regulating plant growth and development processes, including reproduction. Propagation technologies that employ growth regulators are a vital tool in modern horticulture, agriculture, and biotechnology, enabling the production of high-quality planting material and enhancing production efficiency. The aim of this study was to analyse current approaches to the use of both natural and synthetic growth stimulators based on nitrogen-containing heterocycles in plant propagation, and to further determine the prospects for their application. It has been established that nitrogen-containing natural and synthetic growth regulators are most effectively used for the rooting of cuttings, microclonal propagation (in vitro culture), seed pre-treatment, and the regulation of flowering and fruiting processes. Current strategies for the application of growth stimulators based on nitrogen-containing heterocycles have been systematised, and modern approaches to the development of new, highly efficient compounds using molecular modelling have been outlined. It was demonstrated that the integration of different pharmacophoric fragments within a single molecule can significantly enhance biological activity. Furthermore, the use of newly synthesised compounds, multicomponent formulations, methods for improving their efficiency, and controlled-release systems has shown high effectiveness. The practical significance of this work lays in its potential to guide the development and application of more effective growth stimulators, thereby improving plant propagation efficiency, increasing crop productivity, and optimising biotechnological processes in agriculture and plant science

Keywords

quinoline and succinate derivatives; hybrid molecules; vegetative propagation of plants; microclonal propagation; mixtures of growth stimulators; quinoline derivatives

Suggested citation
Zavhorodnii, M., Gencheva, V., Shupeniuk, V., Brazhko, O., & Horban, V. (2026). Prospects for the use of growth stimulators based on nitrogen-containing heterocycles in plant propagation technologies. Biological Systems: Theory and Innovation, 17(2), 63-75. https://doi.org/10.31548/biologiya/2.2026.63
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